The smoke characteristics of the organic–inorganic hybrid polymer materials (SSP) used in the building decoration were investigated by smoke density test (SDT) and cone calorimeter-Fourier-transform infrared spectroscopy (CC-FTIR). The effects on the organisms were further studied by mice experiments. The SDT results showed that the absorbance of SSP was much lower than that of the polyurethane with or without fire retardant. The CC-FTIR results indicated that the toxic components, such as CO, CO2, HCN and NOx , in the smoke of SSP were kept at the low level. In the mice experiments, no more than two mice died under 300 °C. Although more mice died when the heating temperature increased to 600 and 900 °C, the dead number was lower than that of polymer materials. Furthermore, the cycle number also showed the good healthy condition of the mice in the experiments about SSP.